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In addition, new strategies have recently been explored to upregulate the expression of drug-metabolizing enzymes in cell lines of a human origin i. Among metabolic-based drug-drug interactions, P inhibition seems to be the most important.
A major application of recombinant models expressing a single P is the screening of potential enzyme inhibitors. Therefore, pharmaceutical companies increasingly make use of cell lines to speed up the selection of new drugs with favourable pharmacokinetic and metabolic properties.
Abstract Primary cultured hepatocytes are a valuable in vitro model for drug metabolism studies. Sign In Register. Sign Out Sign In Register. Latest Insider. Check out the latest Insider stories here. More from the IDG Network. Join the Network World communities on Facebook and LinkedIn to comment on topics that are top of mind.
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